SCHEMBL30213362

SCHEMBL30213362

O=C1CCC(N2Cc3ccc(NC(=O)c4ccccc4)cc3C2=O)C(=O)N1

nearest known ligand 0.85

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 19/20 0.85
CSNK1A1 P48729 8/20 0.85
GSPT1 P15170 2/20 0.56
DDB1 Q16531 1/20 0.53
IKZF2 Q9UKS7 6/20 0.52
MAP1LC3B Q9GZQ8 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27387190 0.92 CRBN (1.00) CRBNCSNK1A1GSPT1DDB1IKZF2
SCHEMBL23534534 0.85 CRBN (0.68) CRBNCSNK1A1GSPT1DDB1IKZF2
SCHEMBL30707621 0.85 CRBN (0.74) CRBNCSNK1A1IKZF2MAP1LC3B
SCHEMBL27387221 0.85 CRBN (0.86) CRBNCSNK1A1IKZF2
SCHEMBL32664854 0.85 CRBN (0.86) CRBNCSNK1A1GSPT1DDB1IKZF2
SCHEMBL27387088 0.85 CRBN (0.86) CRBNCSNK1A1GSPT1DDB1IKZF2
SCHEMBL30213435 0.84 CRBN (0.62) CRBNCSNK1A1GSPT1DDB1IKZF2
SCHEMBL27387109 0.84 CRBN (0.84) CRBNCSNK1A1IKZF2
SCHEMBL31158945 0.84 CRBN (0.82) CRBNCSNK1A1GSPT1DDB1IKZF2
SCHEMBL23534376 0.84 CRBN (0.61) CRBNCSNK1A1GSPT1DDB1IKZF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115768768-A Galectin-3 inhibitors 百时美施贵宝公司 2023-03-07 CN disclosed