SCHEMBL30213435

SCHEMBL30213435

COc1ccccc1C(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2

nearest known ligand 0.62

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 17/20 0.62
CSNK1A1 P48729 8/20 0.62
IKZF2 Q9UKS7 6/20 0.60
GSPT1 P15170 2/20 0.53
MEN1 O00255 1/20 0.52
POLB P06746 1/20 0.52
KMT2A Q03164 1/20 0.52
RXFP1 Q9HBX9 1/20 0.52
CASP3 P42574 2/20 0.51
DDB1 Q16531 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30213232 0.93 CRBN (0.73) CRBNCSNK1A1IKZF2GSPT1DDB1
SCHEMBL30213434 0.86 CRBN (0.56) CRBNCSNK1A1IKZF2GSPT1DDB1
SCHEMBL30213362 0.84 CRBN (0.85) CRBNCSNK1A1IKZF2GSPT1DDB1
SCHEMBL27387229 0.82 CRBN (0.67) CRBNCSNK1A1IKZF2GSPT1DDB1
SCHEMBL32665096 0.82 CRBN (0.67) CRBNCSNK1A1IKZF2GSPT1DDB1
SCHEMBL30213319 0.82 CRBN (0.69) CRBNCSNK1A1IKZF2
SCHEMBL23534534 0.82 CRBN (0.68) CRBNCSNK1A1IKZF2GSPT1DDB1
SCHEMBL30213409 0.81 CRBN (0.68) CRBNCSNK1A1IKZF2GSPT1DDB1
SCHEMBL30707716 0.81 CRBN (0.76) CRBNCSNK1A1IKZF2GSPT1DDB1
SCHEMBL27471282 0.81 CRBN (0.76) CRBNCSNK1A1IKZF2GSPT1DDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115768768-A Galectin-3 inhibitors 百时美施贵宝公司 2023-03-07 CN disclosed