Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.36 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22720838 | 0.75 | NR1H2 (0.41) | KDM4EMAPTTHRBBUB1MAPK1 | |
| SCHEMBL2600437 | 0.73 | SMN1; SMN2 (0.56) | KDM4EMAPTTHRBGPR119BUB1 | |
| Acetic Acid SCHEMBL28215593 | 0.71 | SMN1; SMN2 (0.40) | KDM4EMAPTTHRBGPR119BUB1 | |
| SCHEMBL28831819 | 0.71 | ESR2 (0.40) | KDM4EMAPTTHRBGPR119BUB1 | |
| SCHEMBL3110330 | 0.71 | MAPT (0.36) | KDM4EMAPTTHRBBUB1ESR2 | |
| SCHEMBL1199488 | 0.71 | GPR119 (0.39) | KDM4EMAPTTHRBGPR119MAPK1 | |
| SCHEMBL28688256 | 0.70 | ESR2 (0.41) | KDM4EMAPTTHRBGPR119BUB1 | |
| SCHEMBL7381748 | 0.70 | USP2 (0.35) | KDM4EMAPTTHRBGPR119MAPK1 | |
| SCHEMBL8120965 | 0.70 | ESR2 (0.38) | KDM4EMAPTTHRBESR2USP2 | |
| SCHEMBL31165785 | 0.68 | MAPK1 (0.34) | KDM4EMAPTTHRBMAPK1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4142874-B1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC (JP) | 2026-04-22 | — | — | EP | disclosed |
| CN-115427409-B | Pyrimidine-4 (3H) -one derivatives as TRPV4 antagonists | 拉夸里亚创药株式会社 | 2025-02-25 | — | — | CN | disclosed |
| EP-4142874-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RaQualia Pharma Inc. (JP) | 2023-03-08 | — | — | EP | disclosed |