Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | RAC1 | P63000 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30213714 | 0.95 | EGFR (0.49) | EGFRCSNK2A1RAC1SRCPIK3CA | |
| SCHEMBL30213747 | 0.84 | AIMP2 (0.45) | EGFRKDRSRC | |
| SCHEMBL28546121 | 0.84 | AIMP2 (0.45) | EGFRKDRSRC | |
| SCHEMBL30213753 | 0.83 | EGFR (0.47) | EGFRCSNK2A1RAC1FLT3KDR | |
| SCHEMBL30213605 | 0.81 | EGFR (0.45) | EGFRCSNK2A1KDRSRC | |
| SCHEMBL30213670 | 0.78 | EGFR (0.54) | EGFRFLT3EPHX2KDRSRC | |
| SCHEMBL28539892 | 0.77 | EGFR (0.37) | EGFR | |
| SCHEMBL28539895 | 0.75 | EGFR (0.48) | EGFRCSNK2A1KDR | |
| SCHEMBL29578659 | 0.74 | EGFR (0.92) | EGFRFLT3KDRSRC | |
| SCHEMBL28540776 | 0.74 | EGFR (0.48) | EGFRCSNK2A1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112574177-B | Pyrimidine derivatives and application thereof in preparing antitumor drugs | 陕西师范大学 | 2023-01-31 | — | — | CN | disclosed |