Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AIMP2 | Q13155 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 7/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 5/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28546121 | 1.00 | AIMP2 (0.45) | AIMP2EGFRJAK2JAK3SRC | |
| SCHEMBL30213714 | 0.89 | EGFR (0.49) | EGFRSRCGAK | |
| SCHEMBL30213776 | 0.84 | EGFR (0.55) | EGFRSRCKDR | |
| SCHEMBL28549641 | 0.81 | EGFR (0.41) | AIMP2EGFRJAK2JAK3GAK | |
| SCHEMBL30213684 | 0.77 | EGFR (0.54) | AIMP2EGFRNTRK1ERBB2 | |
| SCHEMBL28540768 | 0.77 | EGFR (0.54) | AIMP2EGFRNTRK1ERBB2 | |
| SCHEMBL28537354 | 0.72 | EGFR (0.63) | EGFRERBB2 | |
| SCHEMBL28540776 | 0.72 | EGFR (0.48) | EGFRGAKKDRTDO2ERBB2 | |
| SCHEMBL30213605 | 0.71 | EGFR (0.45) | EGFRJAK2JAK3SRCFGFR1 | |
| SCHEMBL22338207 | 0.70 | EGFR (0.80) | EGFRJAK2JAK3SRCGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112574177-B | Pyrimidine derivatives and application thereof in preparing antitumor drugs | 陕西师范大学 | 2023-01-31 | — | — | CN | disclosed |