Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.70 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24954299 | 1.00 | MAP4K1 (0.70) | MAP4K1NR1H2NR1H3MAP3K5GPR119 | |
| SCHEMBL30893063 | 1.00 | MAP4K1 (0.70) | MAP4K1NR1H2NR1H3MAP3K5GPR119 | |
| SCHEMBL30893059 | 0.88 | MAP4K1 (0.67) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL24954369 | 0.88 | MAP4K1 (0.67) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858850 | 0.87 | MAP4K1 (0.88) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29609216 | 0.87 | MAP4K1 (0.88) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL24955691 | 0.86 | MAP4K1 (0.66) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL30893068 | 0.86 | MAP4K1 (0.66) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL24954419 | 0.84 | MAP4K1 (0.58) | MAP4K1MAP3K5GPR119ROCK2 | |
| SCHEMBL30215935 | 0.84 | MAP4K1 (0.58) | MAP4K1MAP3K5GPR119ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377318-A1 | PYRROLO [2, 3-B] PYRAZINE-BASED BIFUNCTIONAL COMPOUNDS AS HPK1 DEGRADERS AND THE USE THEREOF | BeiGene, Ltd. (KY) | 2024-06-05 | — | — | EP | disclosed |
| CN-118043324-A | Pyrrolo [2,3-b ] pyrazine-based bifunctional compounds as HPK1 degradants and uses thereof | 百济神州有限公司 | 2024-05-14 | — | — | CN | disclosed |
| WO-2023006063-A1 | PYRROLO [2, 3-b] PYRAZINE-BASED BIFUNCTIONAL COMPOUNDS AS HPK1 DEGRADERS AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2023-02-02 | — | — | WO | disclosed |