Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.67 |
| ▸ | INSR | P06213 | 1/20 | 0.57 |
| ▸ | IGF1R | P08069 | 1/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
| ▸ | ROS1 | P08922 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | FER | P16591 | 1/20 | 0.54 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.54 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.54 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25449097 | 1.00 | EGFR (0.67) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL25450025 | 0.95 | EGFR (0.60) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL24179047 | 0.94 | EGFR (0.65) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL25450645 | 0.93 | INSR (0.59) | EGFRINSRIGF1RALKPDGFRB | |
| SCHEMBL31291051 | 0.93 | EGFR (0.57) | EGFRALKCHEK1AURKACCNT1 | |
| SCHEMBL24179405 | 0.93 | EGFR (0.57) | EGFRALKCHEK1AURKACCNT1 | |
| SCHEMBL24179127 | 0.93 | EGFR (0.66) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL25450051 | 0.93 | EGFR (0.66) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL24179375 | 0.93 | EGFR (0.58) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL24178983 | 0.92 | EGFR (0.58) | EGFRINSRIGF1RALKCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023025164-A1 | CRYSTAL FORMS, PREPARATION METHOD AND APPLICATION OF ARYL PHOSPHINE OXIDE COMPOUND | 成都地奥九泓制药厂 | 2023-03-02 | — | — | WO | disclosed |