Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL236107 | 1.00 | KDM4E (0.47) | KDM4EGAALMNAMAPK1ABL1 | |
| SCHEMBL977733 | 0.87 | KDM4E (0.49) | KDM4EGAALMNAMAPK1ABL1 | |
| SCHEMBL29416286 | 0.87 | KDM4E (0.49) | KDM4EGAALMNAMAPK1ABL1 | |
| SCHEMBL474122 | 0.85 | KDM4E (0.44) | KDM4EGAALMNAMAPK1ABL1 | |
| SCHEMBL29551416 | 0.85 | KDM4E (0.44) | KDM4EGAALMNAMAPK1ABL1 | |
| SCHEMBL18725404 | 0.84 | KDM4E (0.46) | KDM4EGAALMNAMAPK1ABL1 | |
| SCHEMBL4750181 | 0.84 | GAA (0.42) | KDM4EGAALMNAABL1MEN1 | |
| SCHEMBL22321497 | 0.84 | CA12 (0.49) | KDM4EGAALMNAMAPK1ABL1 | |
| SCHEMBL23526212 | 0.82 | KDM4E (0.45) | KDM4EGAALMNAMAPK1ABL1 | |
| SCHEMBL2355355 | 0.82 | GAA (0.53) | KDM4EGAALMNAABL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115667265-A | CGAS-inhibiting triazolopyrimidinone derivatives | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |