Sugi Predict

Sugi Predict / Compounds / SCHEMBL2355355

SCHEMBL2355355

SCHEMBL2355355

COC(=O)c1cc(N)ncc1Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 5/20 0.53
▸ ABL1 P00519 1/20 0.47
▸ KDM4E B2RXH2 5/20 0.46
▸ TSHR P16473 2/20 0.45
▸ NQO2 P16083 5/20 0.44
▸ MAPT P10636 3/20 0.44
▸ ALDH1A1 P00352 4/20 0.44
▸ GLA P06280 2/20 0.44
▸ POLB P06746 1/20 0.42
▸ GABRP O00591 2/20 0.42
▸ GABRD O14764 2/20 0.42
▸ GABRA1 P14867 2/20 0.42
▸ GABRB1 P18505 2/20 0.42
▸ GABRG2 P18507 2/20 0.42
▸ GABRB3 P28472 2/20 0.42
▸ GABRA5 P31644 2/20 0.42
▸ GABRA3 P34903 2/20 0.42
▸ GABRA2 P47869 2/20 0.42
▸ GABRB2 P47870 2/20 0.42
▸ GABRA4 P48169 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31472304 1.00 GAA (0.53) GAAABL1KDM4ETSHRNQO2
SCHEMBL25149468 0.86 GAA (0.49) GAAABL1KDM4ETSHRNQO2
SCHEMBL30217866 0.82 KDM4E (0.47) GAAABL1KDM4ETSHRNQO2
SCHEMBL236107 0.82 KDM4E (0.47) GAAABL1KDM4ETSHRNQO2
SCHEMBL31216654 0.81 KDM4E (0.56) GAAABL1KDM4ETSHRMAPT
SCHEMBL4750181 0.81 GAA (0.42) GAAABL1KDM4ETSHRNQO2
SCHEMBL22451734 0.81 KDM4E (0.47) GAAABL1KDM4ETSHRNQO2
SCHEMBL17029063 0.81 GABRP (0.51) GAAABL1KDM4ETSHRNQO2
SCHEMBL25203375 0.80 GAA (0.46) GAAABL1KDM4ETSHRNQO2
SCHEMBL339661 0.79 KDM4E (0.46) GAAABL1KDM4ETSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250188070-A1 ANTIPROLIFERATION COMPOUNDS AND USES THEREOF VERTEX PHARMACEUTICALS INCORPORATED 2025-06-12 — — US disclosed
US-12195453-B2 Antiproliferation compounds and uses thereof MERCK PATENT GMBH (DE) 2025-01-14 — — US disclosed
EP-4043460-B1 ANTIPROLIFERATION COMPOUNDS AND USES THEREOF MERCK PATENT GMBH (DE) 2024-06-05 — — EP disclosed
US-20230150993-A1 ANTIPROLIFERATION COMPOUNDS AND USES THEREOF VERTEX PHARMACEUTICALS INCORPORATED 2023-05-18 — — US disclosed
US-20230150993-A1 ANTIPROLIFERATION COMPOUNDS AND USES THEREOF VERTEX PHARMACEUTICALS INCORPORATED 2023-05-18 — — US disclosed
US-20230150993-A1 ANTIPROLIFERATION COMPOUNDS AND USES THEREOF VERTEX PHARMACEUTICALS INCORPORATED 2023-05-18 — — US disclosed
WO-2023060173-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF USE AQUINNAH PHARMACEUTICALS, INC. (US) 2023-04-13 — — WO disclosed
US-11440907-B1 Antiproliferation compounds and uses thereof MERCK PATENT GMBH (DE) 2022-09-13 — — US disclosed
EP-4043460-A1 ANTIPROLIFERATION COMPOUNDS AND USES THEREOF Merck Patent GmbH (DE) 2022-08-17 — — EP disclosed
EP-4043460-A1 ANTIPROLIFERATION COMPOUNDS AND USES THEREOF Merck Patent GmbH (DE) 2022-08-17 — — EP disclosed
WO-2016089990-A1 SULFIDE ALKYL AND PYRIDYL REVERSE SULFONAMIDE COMPOUNDS FOR HBV TREATMENT NOVIRA THERAPEUTICS, INC. (US) 2016-06-09 — — WO disclosed
CN-102317263-B Halogen substituted compounds as pesticides BAYER IP GMBH 2015-04-22 — — CN disclosed
US-20150099766-A1 Novel halogen-substituted compounds BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-04-09 — — US disclosed
US-8946234-B2 Halogen-substituted compounds BAYER CROPSCIENCE AG (DE) 2015-02-03 — — US disclosed
WO-2013173382-A1 BENZOTHIOPHENE SULFONAMIDES AND OTHER COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN AMGEN INC. (US) 2013-11-21 — — WO disclosed
CN-102317263-A Halogen substituted compounds as pesticides BAYER CROPSCIENCE AG 2012-01-11 — — CN disclosed
US-20110301181-A1 halogen-substituted compounds BAYER CROPSCIENCE AG (DE) 2011-12-08 — — US disclosed
EP-2352723-A2 HALOGEN-SUBSTITUTED COMPOUNDS USED AS PESTICIDES Bayer CropScience AG (DE) 2011-08-10 — — EP disclosed
WO-2010133312-A1 HALOGEN-SUBSTITUTED COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-11-25 — — WO disclosed
WO-2010051926-A2 NEW HALOGEN-SUBSTITUTED BONDS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-05-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110301181-A1 halogen-substituted compounds L3MBTL4, QSOX1, L3MBTL3 GAA 2325/4885ABL1 314/4885KDM4E 2403/4885
US-12195453-B2 Antiproliferation compounds and uses thereof MKI67, MCL1, CCNI GAA 488/4885ABL1 303/4885KDM4E 2013/4885
US-11440907-B1 Antiproliferation compounds and uses thereof MKI67, MCL1, CCNI GAA 488/4885ABL1 303/4885KDM4E 2013/4885
US-20230150993-A1 ANTIPROLIFERATION COMPOUNDS AND USES THEREOF MKI67, MCL1, CCNI GAA 488/4885ABL1 303/4885KDM4E 2013/4885
US-20250188070-A1 ANTIPROLIFERATION COMPOUNDS AND USES THEREOF MKI67, MCL1, CCNI GAA 488/4885ABL1 303/4885KDM4E 2013/4885
US-20150099766-A1 Novel halogen-substituted compounds L3MBTL4, PRDX4, PRDX1 GAA 2771/4885ABL1 362/4885KDM4E 1987/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.