Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 3/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.36 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29213370 | 1.00 | GRN (0.40) | GRNSORT1KDM1AMAOAMAOB | |
| SCHEMBL29213373 | 1.00 | GRN (0.40) | GRNSORT1KDM1AMAOAMAOB | |
| SCHEMBL29213268 | 0.86 | GRN (0.44) | GRNSORT1PDCD1CD274 | |
| SCHEMBL29213264 | 0.86 | GRN (0.44) | GRNSORT1PDCD1CD274 | |
| SCHEMBL30903312 | 0.84 | GRN (0.42) | GRNSORT1CYP11B1CYP11B2PDCD1 | |
| SCHEMBL29213469 | 0.84 | GRN (0.42) | GRNSORT1CYP11B1CYP11B2PDCD1 | |
| SCHEMBL29213472 | 0.84 | GRN (0.42) | GRNSORT1CYP11B1CYP11B2PDCD1 | |
| SCHEMBL30903307 | 0.83 | GRN (0.44) | GRNSORT1 | |
| SCHEMBL29213362 | 0.83 | GRN (0.44) | GRNSORT1 | |
| SCHEMBL29213359 | 0.83 | GRN (0.44) | GRNSORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118019533-A | 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases | 因苏森斯有限公司 | 2024-05-10 | — | — | CN | claimed |
| EP-4395776-A1 | 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM | Insusense ApS (DK) | 2024-07-10 | — | — | EP | disclosed |
| CN-118019533-A | 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases | 因苏森斯有限公司 | 2024-05-10 | — | — | CN | disclosed |
| WO-2023031440-A1 | 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM | INSUSENSE ApS (DK) | 2023-03-09 | — | — | WO | disclosed |