Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 4/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | GGT1 | P19440 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29213469 | 1.00 | GRN (0.42) | GRNSORT1CYP2C9NAMPTCTSB | |
| SCHEMBL30903312 | 1.00 | GRN (0.42) | GRNSORT1CYP2C9NAMPTCTSB | |
| SCHEMBL29213362 | 0.86 | GRN (0.44) | GRNSORT1GGT1HCAR2CYP3A4 | |
| SCHEMBL30903307 | 0.86 | GRN (0.44) | GRNSORT1GGT1HCAR2CYP3A4 | |
| SCHEMBL29213359 | 0.86 | GRN (0.44) | GRNSORT1GGT1HCAR2CYP3A4 | |
| SCHEMBL29213370 | 0.84 | GRN (0.40) | GRNSORT1PDCD1CD274CYP11B1 | |
| SCHEMBL30219085 | 0.84 | GRN (0.40) | GRNSORT1PDCD1CD274CYP11B1 | |
| SCHEMBL29213373 | 0.84 | GRN (0.40) | GRNSORT1PDCD1CD274CYP11B1 | |
| SCHEMBL29213329 | 0.84 | GRN (0.43) | GRNSORT1CYP2C9NAMPTPYGL | |
| SCHEMBL29213336 | 0.84 | GRN (0.43) | GRNSORT1CYP2C9NAMPTPYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118019533-A | 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases | 因苏森斯有限公司 | 2024-05-10 | — | — | CN | claimed |
| CN-118019533-A | 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases | 因苏森斯有限公司 | 2024-05-10 | — | — | CN | disclosed |