Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.51 |
| ▸ | DHFR | P00374 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.36 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25402966 | 1.00 | MAP3K14 (0.51) | MAP3K14DHFRPDE4AEGFRFGFR1 | |
| SCHEMBL25401767 | 0.82 | DHFR (0.44) | MAP3K14DHFRPDE4AEGFRSRC | |
| SCHEMBL30219555 | 0.76 | MAPKAPK2 (0.55) | MAP3K14DHFREGFRFGFR1SRC | |
| SCHEMBL25402204 | 0.76 | MAPKAPK2 (0.55) | MAP3K14DHFREGFRFGFR1SRC | |
| SCHEMBL30219641 | 0.75 | DHFR (0.49) | DHFRPDE4AEGFRMEN1KMT2A | |
| SCHEMBL28301793 | 0.75 | DHFR (0.49) | DHFRPDE4AEGFRMEN1KMT2A | |
| SCHEMBL25400343 | 0.73 | MAP3K14 (0.56) | MAP3K14 | |
| SCHEMBL26268315 | 0.73 | MAP3K14 (0.56) | MAP3K14 | |
| SCHEMBL30219530 | 0.66 | MAP3K14 (0.52) | MAP3K14DHFREGFRMEN1KMT2A | |
| SCHEMBL25400261 | 0.65 | PTK2 (0.38) | MAP3K14DHFRPDE4AEGFRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109810110-B | Compound with 2-aminopyrimidine structure, preparation method and application thereof | 中国科学院上海药物研究所 | 2023-01-24 | — | — | CN | disclosed |