Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2009112 | 1.00 | POLB (0.63) | POLBNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL232841 | 0.94 | POLB (0.69) | POLBNPC1RAB9ASMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL25310714 | 0.93 | POLB (0.68) | POLBNPC1RAB9ASMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL2966520 | 0.93 | POLB (0.68) | POLBNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL9105524 | 0.87 | POLB (0.75) | POLBNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL2365866 | 0.80 | ADRB1 (0.51) | POLBNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1999759 | 0.79 | POLB (0.71) | POLBNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL2575981 | 0.79 | ADRB1 (0.50) | POLBNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4907149 | 0.79 | POLB (0.71) | POLBNPC1RAB9ASMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL25426101 | 0.77 | ADRB1 (0.49) | POLBNPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373808-A1 | GRAM-NEGATIVE BACTERIA EFFLUX PUMP INHIBITORS | Institut national de la santé et de la recherche médicale (INSERM) (FR) | 2024-05-29 | — | — | EP | claimed |
| CN-118076585-A | Gram negative bacteria efflux pump inhibitors | 国家医疗保健研究所 | 2024-05-24 | — | — | CN | claimed |
| WO-2023002011-A1 | GRAM-NEGATIVE BACTERIA EFFLUX PUMP INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2023-01-26 | — | — | WO | claimed |
| EP-4373808-A1 | GRAM-NEGATIVE BACTERIA EFFLUX PUMP INHIBITORS | Institut national de la santé et de la recherche médicale (INSERM) (FR) | 2024-05-29 | — | — | EP | disclosed |
| CN-118076585-A | Gram negative bacteria efflux pump inhibitors | 国家医疗保健研究所 | 2024-05-24 | — | — | CN | disclosed |
| WO-2023002011-A1 | GRAM-NEGATIVE BACTERIA EFFLUX PUMP INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2023-01-26 | — | — | WO | disclosed |