Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | HCK | P08631 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23994016 | 1.00 | SYK (0.36) | SYKACP1MTORMTNR1AMTNR1B | |
| SCHEMBL30224517 | 0.92 | MTOR (0.33) | SYKACP1MTORPPARDEGFR | |
| SCHEMBL30224245 | 0.92 | MTOR (0.33) | SYKACP1MTORMTNR1AMTNR1B | |
| SCHEMBL23992930 | 0.92 | MTOR (0.33) | SYKACP1MTORMTNR1AMTNR1B | |
| SCHEMBL25005301 | 0.92 | MTOR (0.33) | SYKACP1MTORPPARDEGFR | |
| SCHEMBL30224304 | 0.90 | ACP1 (0.36) | SYKACP1MTORPPARDEGFR | |
| SCHEMBL23993543 | 0.89 | ACP1 (0.38) | SYKACP1MTORPPARDPTGES2 | |
| SCHEMBL30224725 | 0.89 | ACP1 (0.38) | SYKACP1MTORPPARDPTGES2 | |
| SCHEMBL25005777 | 0.89 | SYK (0.41) | SYKACP1MTORPPARDPTGES2 | |
| SCHEMBL23994827 | 0.89 | SYK (0.41) | SYKACP1MTORPPARDPTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143194-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-03-08 | — | — | EP | disclosed |