Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 10/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 5/20 | 0.32 |
| ▸ | MDM4 | O15151 | 1/20 | 0.32 |
| ▸ | ACP1 | P24666 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BRD2 | P25440 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23994025 | 1.00 | RIPK1 (0.34) | RIPK1MDM2PPARDALDH1A1CYP1A2 | |
| SCHEMBL23993449 | 0.90 | PPARD (0.34) | MDM2PPARDALDH1A1CYP1A2TSHR | |
| SCHEMBL30224763 | 0.86 | RIPK1 (0.37) | RIPK1MDM2PPARDALDH1A1CYP1A2 | |
| SCHEMBL23993997 | 0.86 | RIPK1 (0.37) | RIPK1MDM2PPARDALDH1A1CYP1A2 | |
| SCHEMBL23994177 | 0.85 | MDM2 (0.39) | MDM2PPARDMTORTP53MDM4 | |
| SCHEMBL30224155 | 0.84 | MTOR (0.38) | MDM2PPARDALDH1A1CYP1A2MTOR | |
| SCHEMBL23992885 | 0.84 | MTOR (0.38) | MDM2PPARDALDH1A1CYP1A2MTOR | |
| SCHEMBL30224921 | 0.83 | RIPK1 (0.36) | RIPK1MDM2PPARDALDH1A1CYP1A2 | |
| SCHEMBL23993472 | 0.83 | MTOR (0.33) | RIPK1MDM2ALDH1A1CYP1A2TSHR | |
| SCHEMBL23994933 | 0.82 | RIPK1 (0.36) | RIPK1MDM2PPARDALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143194-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-03-08 | — | — | EP | disclosed |