Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23994950 | 1.00 | PPARD (0.34) | PPARDMDM2MTORSYKTP53 | |
| SCHEMBL23994033 | 0.90 | MTOR (0.35) | PPARDMDM2MTORSYKTP53 | |
| SCHEMBL23993616 | 0.87 | SYK (0.34) | PPARDMDM2MTORSYK | |
| SCHEMBL30224370 | 0.87 | SYK (0.34) | PPARDMDM2MTORSYK | |
| SCHEMBL23993568 | 0.87 | SYK (0.34) | PPARDMDM2MTORSYK | |
| SCHEMBL23993918 | 0.86 | SYK (0.38) | PPARDMDM2MTORSYKTP53 | |
| SCHEMBL30224718 | 0.86 | RAF1 (0.32) | PPARDMDM2MTOR | |
| SCHEMBL30224623 | 0.86 | RAF1 (0.32) | PPARDMDM2MTOR | |
| SCHEMBL23994060 | 0.86 | JAK2 (0.35) | PPARDMDM2MTORSYKTP53 | |
| SCHEMBL23992937 | 0.85 | JAK2 (0.39) | PPARDMDM2MTORSYKTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143194-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-03-08 | — | — | EP | disclosed |