Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27209478 | 1.00 | CYP1A2 (0.33) | CYP1A2GAAKDM4EMAPTHDAC1 | |
| SCHEMBL23975730 | 0.80 | POLB (0.40) | CYP1A2GAAKDM4EMAPTHDAC1 | |
| SCHEMBL30225189 | 0.80 | POLB (0.40) | CYP1A2GAAKDM4EMAPTHDAC1 | |
| SCHEMBL30118771 | 0.79 | PDE10A (0.42) | CYP1A2HDAC1HDAC8HDAC6 | |
| SCHEMBL23976240 | 0.79 | PDE10A (0.42) | CYP1A2HDAC1HDAC8HDAC6 | |
| SCHEMBL23975882 | 0.79 | HDAC1 (0.33) | CYP1A2GAAKDM4EMAPTHDAC1 | |
| SCHEMBL23976616 | 0.79 | HCRTR2 (0.31) | HDAC1HDAC8HDAC6 | |
| SCHEMBL30118716 | 0.79 | HCRTR2 (0.31) | HDAC1HDAC8HDAC6 | |
| SCHEMBL23975763 | 0.78 | POLB (0.38) | CYP1A2GAAKDM4EMAPTHDAC1 | |
| SCHEMBL23976317 | 0.77 | ACHE (0.33) | CYP1A2GAAKDM4EMAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4142732-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2023-03-08 | — | — | EP | disclosed |
| EP-4143178-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2023-03-08 | — | — | EP | disclosed |