Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 9/20 | 0.33 |
| ▸ | PPARA | Q07869 | 9/20 | 0.33 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23976269 | 1.00 | MEN1 (0.41) | MEN1KMT2ANPC1RAB9AKDM4C | |
| SCHEMBL23976268 | 0.91 | MEN1 (0.37) | MEN1KMT2ANPC1RAB9AKDM4C | |
| SCHEMBL30225198 | 0.91 | MEN1 (0.37) | MEN1KMT2ANPC1RAB9AKDM4C | |
| SCHEMBL30118714 | 0.90 | MEN1 (0.37) | MEN1KMT2ANPC1RAB9AKDM4C | |
| SCHEMBL23975778 | 0.90 | MEN1 (0.37) | MEN1KMT2ANPC1RAB9AKDM4C | |
| SCHEMBL23975872 | 0.90 | LMNA (0.39) | MEN1KMT2ANPC1RAB9AHDAC1 | |
| SCHEMBL30225292 | 0.90 | LMNA (0.39) | MEN1KMT2ANPC1RAB9AHDAC1 | |
| SCHEMBL23976646 | 0.88 | MEN1 (0.35) | MEN1KMT2ANPC1RAB9AKDM4C | |
| SCHEMBL30225268 | 0.88 | MEN1 (0.35) | MEN1KMT2ANPC1RAB9AKDM4C | |
| SCHEMBL23976665 | 0.85 | NPC1 (0.34) | MEN1KMT2ANPC1RAB9AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4142732-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2023-03-08 | — | — | EP | disclosed |
| EP-4143178-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2023-03-08 | — | — | EP | disclosed |