Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | IGLV6-57 | P01721 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30228044 | 0.91 | ALDH1A1 (0.60) | ALDH1A1HPGDKDM4ECYP3A4CYP2C9 | |
| SCHEMBL20839088 | 0.91 | ALDH1A1 (0.64) | ALDH1A1HPGDKDM4ECYP3A4CYP2C9 | |
| SCHEMBL30058097 | 0.91 | ALDH1A1 (0.64) | ALDH1A1HPGDKDM4ECYP3A4CYP2C9 | |
| SCHEMBL20839423 | 0.90 | ALDH1A1 (0.63) | ALDH1A1HPGDKDM4ECYP3A4CYP2C9 | |
| SCHEMBL20839424 | 0.90 | ALDH1A1 (0.63) | ALDH1A1HPGDKDM4ECYP3A4CYP2C9 | |
| SCHEMBL20839420 | 0.87 | ALDH1A1 (0.60) | ALDH1A1HPGDKDM4ECYP3A4CYP2C9 | |
| SCHEMBL30055262 | 0.87 | ALDH1A1 (0.60) | ALDH1A1HPGDKDM4ECYP3A4CYP2C9 | |
| SCHEMBL22406277 | 0.84 | CYP3A4 (0.58) | ALDH1A1HPGDKDM4ECYP3A4CYP2C9 | |
| SCHEMBL20839361 | 0.83 | CYP3A4 (0.60) | ALDH1A1HPGDKDM4ECYP3A4CYP2C9 | |
| SCHEMBL30055773 | 0.83 | CYP3A4 (0.60) | ALDH1A1HPGDKDM4ECYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |