Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 10/20 | 0.69 |
| ▸ | CA9 | Q16790 | 10/20 | 0.69 |
| ▸ | HSD17B3 | P37058 | 4/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | SORD | Q00796 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 3/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20839408 | 1.00 | CA12 (0.69) | CA12CA9HSD17B3AKR1B1MAOB | |
| SCHEMBL30598329 | 0.84 | CA12 (0.63) | CA12CA9HSD17B3AKR1B1MAOB | |
| SCHEMBL20848059 | 0.84 | CA12 (0.61) | CA12CA9HSD17B3AKR1B1MAOB | |
| SCHEMBL30228177 | 0.84 | KDM4E (0.49) | CA12CA9HSD17B3AKR1B1MAOB | |
| SCHEMBL30228096 | 0.84 | CA12 (0.48) | CA12CA9MAOBKDM4EALDH1A1 | |
| SCHEMBL30227956 | 0.84 | CA12 (0.48) | CA12CA9HSD17B3AKR1B1MAOB | |
| SCHEMBL26114135 | 0.84 | CA12 (0.69) | CA12CA9HSD17B3AKR1B1MAOB | |
| SCHEMBL30228052 | 0.83 | CA12 (0.48) | CA12CA9HSD17B3AKR1B1MAOB | |
| SCHEMBL30227959 | 0.83 | CA9 (0.48) | CA12CA9HSD17B3AKR1B1MAOB | |
| SCHEMBL14424515 | 0.82 | CA12 (0.75) | CA12CA9HSD17B3AKR1B1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111386261-B | Coumarin derivatives, process for their preparation and their use in the treatment of cancer | 利德发现中心有限责任公司 | 2024-03-22 | — | — | CN | disclosed |
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |