Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | HPGD | P15428 | 7/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.53 |
| ▸ | SORD | Q00796 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30228433 | 0.87 | KCNA3 (0.46) | ALDH1A1HPGDCA9AKR1B1CA12 | |
| SCHEMBL30228403 | 0.87 | KCNA3 (0.46) | ALDH1A1HPGDCA9AKR1B1CA12 | |
| SCHEMBL14111529 | 0.80 | CA9 (0.62) | ALDH1A1HPGDCA9AKR1B1CA12 | |
| SCHEMBL30228459 | 0.80 | CA9 (0.53) | ALDH1A1HPGDCA9AKR1B1CA12 | |
| SCHEMBL30228175 | 0.79 | KCNA3 (0.47) | ALDH1A1HPGDCA9AKR1B1CA12 | |
| SCHEMBL30228263 | 0.79 | KCNA3 (0.47) | ALDH1A1HPGDCA9AKR1B1CA12 | |
| SCHEMBL31245426 | 0.77 | ALDH1A1 (0.82) | ALDH1A1HPGDCA9MAOBKDM4E | |
| SCHEMBL21629597 | 0.77 | ALDH1A1 (0.82) | ALDH1A1HPGDCA9MAOBKDM4E | |
| SCHEMBL30228036 | 0.74 | KCNA3 (0.41) | ALDH1A1HPGDCA9CA12KDM4E | |
| SCHEMBL14437121 | 0.74 | ALDH1A1 (0.64) | ALDH1A1HPGDCA9AKR1B1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |