Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | IGLV6-57 | P01721 | 3/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | PPARA | Q07869 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30231440 | 1.00 | ALDH1A1 (0.51) | ALDH1A1HPGDIGLV6-57MAOBPPARG | |
| SCHEMBL30231491 | 1.00 | ALDH1A1 (0.51) | ALDH1A1HPGDIGLV6-57MAOBPPARG | |
| SCHEMBL30231492 | 0.92 | ALDH1A1 (0.53) | ALDH1A1HPGDIGLV6-57MAOBPPARG | |
| SCHEMBL30231395 | 0.92 | ALDH1A1 (0.53) | ALDH1A1HPGDIGLV6-57MAOBPPARG | |
| SCHEMBL30231584 | 0.92 | ALDH1A1 (0.53) | ALDH1A1HPGDIGLV6-57MAOBPPARG | |
| SCHEMBL30231607 | 0.91 | IGLV6-57 (0.48) | ALDH1A1HPGDIGLV6-57MAOBPPARG | |
| SCHEMBL30231359 | 0.91 | IGLV6-57 (0.48) | ALDH1A1HPGDIGLV6-57MAOBPPARG | |
| SCHEMBL30231448 | 0.91 | IGLV6-57 (0.48) | ALDH1A1HPGDIGLV6-57MAOBPPARG | |
| SCHEMBL30231536 | 0.90 | ALDH1A1 (0.54) | ALDH1A1HPGDIGLV6-57PPARGPPARA | |
| SCHEMBL30231271 | 0.88 | ALDH1A1 (0.54) | ALDH1A1HPGDIGLV6-57PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |