Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | HPGD | P15428 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30231473 | 0.91 | CA9 (0.54) | CA12CA9ALDH1A1HPGDKDM4E | |
| SCHEMBL30231648 | 0.90 | ALDH1A1 (0.53) | CA12CA9ALDH1A1HPGDKDM4E | |
| SCHEMBL30231510 | 0.88 | CA12 (0.51) | CA12CA9ALDH1A1HPGDKDM4E | |
| SCHEMBL30231628 | 0.88 | CA12 (0.51) | CA12CA9ALDH1A1HPGDKDM4E | |
| SCHEMBL30231442 | 0.87 | HPGD (0.43) | CA12CA9ALDH1A1HPGDKDM4E | |
| SCHEMBL22431754 | 0.82 | CA9 (0.56) | CA12CA9ALDH1A1HPGDKDM4E | |
| SCHEMBL30231415 | 0.80 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4ETDP1RECQL | |
| SCHEMBL30231414 | 0.80 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4ETDP1RECQL | |
| SCHEMBL30231271 | 0.80 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4ETDP1RECQL | |
| SCHEMBL30231699 | 0.80 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4ETDP1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |