Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13733029 | 1.00 | CA1 (0.51) | CA1CA2CA7CA9KMT2A | |
| SCHEMBL29097257 | 1.00 | CA1 (0.51) | CA1CA2CA7CA9KMT2A | |
| SCHEMBL13733023 | 1.00 | CA1 (0.51) | CA1CA2CA7CA9KMT2A | |
| SCHEMBL11402438 | 0.86 | CA1 (0.54) | CA1CA2CA7CA9KMT2A | |
| SCHEMBL27302240 | 0.86 | CA1 (0.54) | CA1CA2CA7CA9KMT2A | |
| SCHEMBL19532528 | 0.86 | CA1 (0.54) | CA1CA2CA7CA9KMT2A | |
| SCHEMBL29926136 | 0.85 | MMP2 (0.41) | CA1CA2CA7CA9KMT2A | |
| SCHEMBL1785824 | 0.85 | CA1 (0.50) | CA1CA2CA7CA9KMT2A | |
| SCHEMBL1785822 | 0.85 | CA1 (0.50) | CA1CA2CA7CA9KMT2A | |
| SCHEMBL4909047 | 0.83 | KMT2A (0.49) | CA1CA2CA7CA9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |