Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.35 |
| ▸ | PDE4A | P27815 | 11/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | LITAF | Q99732 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3023254 | 1.00 | KCNH2 (0.35) | KCNH2FGFR3KDRPDE4BPDE4D | |
| SCHEMBL4233040 | 0.91 | PDE4B (0.36) | KCNH2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4233037 | 0.91 | PDE4B (0.36) | KCNH2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3027613 | 0.90 | GRIN1 (0.33) | KCNH2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3027610 | 0.90 | GRIN1 (0.33) | KCNH2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL10271512 | 0.89 | JAK1 (0.37) | KCNH2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL870527 | 0.89 | PDE4B (0.45) | KCNH2PDE4BMAP4K4CNR2 | |
| SCHEMBL870526 | 0.89 | PDE4B (0.45) | KCNH2PDE4BMAP4K4CNR2 | |
| SCHEMBL3029124 | 0.88 | CNR2 (0.33) | KCNH2FGFR3KDRPDE4BPDE4D | |
| SCHEMBL871632 | 0.88 | CNR2 (0.33) | KCNH2FGFR3KDRPDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2106396-B1 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ALCON RES LTD (US) | 2014-09-24 | — | — | EP | disclosed |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | ALCON RESEARCH, LTD. | 2010-08-12 | — | — | US | disclosed |
| US-20090124596-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124596-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | KCNH2 3141/4885FGFR3 2966/4885KDR 3013/4885 |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | PDE4A, PDE4B, PDE5A | KCNH2 3031/4885FGFR3 2248/4885KDR 1983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.