Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3023251 | 1.00 | PDE4B (0.46) | PDE4BCYP3A4CNR2PDE4DKCNH2 | |
| SCHEMBL3023352 | 0.91 | PDE4B (0.50) | PDE4BCYP3A4CNR2PDE4DKCNH2 | |
| SCHEMBL872008 | 0.91 | PDE4B (0.50) | PDE4BCYP3A4CNR2PDE4DKCNH2 | |
| SCHEMBL872273 | 0.89 | PDE4B (0.49) | PDE4BCYP3A4CNR2PDE4DKCNH2 | |
| SCHEMBL3016550 | 0.89 | PDE4B (0.49) | PDE4BCYP3A4CNR2PDE4DKCNH2 | |
| SCHEMBL870373 | 0.88 | PDE4B (0.44) | PDE4BTNKSSMYD3 | |
| SCHEMBL871791 | 0.88 | SIRT1 (0.38) | PDE4BCYP3A4CNR2TNKSSMYD3 | |
| SCHEMBL871792 | 0.88 | SIRT1 (0.38) | PDE4BCYP3A4CNR2TNKSSMYD3 | |
| SCHEMBL3032974 | 0.88 | PDE4B (0.51) | PDE4BCYP3A4CNR2PDE4DKCNH2 | |
| SCHEMBL3032976 | 0.88 | PDE4B (0.51) | PDE4BCYP3A4CNR2PDE4DKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | ALCON RESEARCH, LTD. | 2010-08-12 | — | — | US | disclosed |
| US-20090124596-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124596-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | PDE4B 2/4885CYP3A4 116/4885CNR2 2229/4885 |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | PDE4A, PDE4B, PDE5A | PDE4B 2/4885CYP3A4 73/4885CNR2 3682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.