Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piboserod. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 known ✓ | Q13639 | 17/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.78 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.78 |
| ▸ | HRH2 | P25021 | 1/20 | 0.78 |
| ▸ | HTR1D | P28221 | 1/20 | 0.78 |
| ▸ | HTR2A | P28223 | 1/20 | 0.78 |
| ▸ | HRH1 | P35367 | 1/20 | 0.78 |
| ▸ | HTR2B | P41595 | 1/20 | 0.78 |
| ▸ | HTR3A | P46098 | 1/20 | 0.78 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piboserod SCHEMBL467339 | 1.00 | HTR4 (1.00) | HTR4CHRM2ADRA2BHRH2HTR1D | |
| Piboserod SCHEMBL2228911 | 0.99 | HTR4 (0.98) | HTR4CHRM2ADRA2BHRH2HTR1D | |
| SCHEMBL7333331 | 0.91 | HTR4 (0.82) | HTR4CHRM2ADRA2BHRH2HTR1D | |
| SCHEMBL8286732 | 0.90 | HTR4 (1.00) | HTR4CHRM2ADRA2BHRH2HTR1D | |
| SCHEMBL7365338 | 0.90 | HTR4 (0.82) | HTR4CHRM2ADRA2BHRH2HTR1D | |
| SCHEMBL6909544 | 0.89 | HTR4 (1.00) | HTR4CHRM2ADRA2BHRH2HTR1D | |
| SCHEMBL8287824 | 0.89 | HTR4 (1.00) | HTR4CHRM2ADRA2BHRH2HTR1D | |
| SCHEMBL8423110 | 0.88 | HTR4 (0.79) | HTR4CHRM2ADRA2BHRH2HTR1D | |
| SCHEMBL8287825 | 0.88 | HTR4 (1.00) | HTR4CHRM2ADRA2BHRH2HTR1D | |
| SCHEMBL8421844 | 0.88 | HTR4 (0.79) | HTR4CHRM2ADRA2BHRH2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115772157-B | Preparation method of 2-alkoxyindole compound | 浙江理工大学 | 2024-04-02 | — | — | CN | disclosed |
| CN-115772157-A | Preparation method of 2-alkoxy indole compound | 浙江理工大学 | 2023-03-10 | — | — | CN | disclosed |