Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.53 |
| ▸ | LCK | P06239 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | JAK3 | P52333 | 3/20 | 0.53 |
| ▸ | BRAF | P15056 | 3/20 | 0.52 |
| ▸ | TEK | Q02763 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29272411 | 1.00 | MAPK14 (0.53) | MAPK14LCKKDRJAK3BRAF | |
| SCHEMBL30236923 | 0.90 | ORAI1 (0.46) | MAPK14LCKKDRJAK3BRAF | |
| SCHEMBL29272363 | 0.90 | ORAI1 (0.46) | MAPK14LCKKDRJAK3BRAF | |
| SCHEMBL29272232 | 0.85 | RAF1 (0.56) | MAPK14LCKKDRJAK3BRAF | |
| SCHEMBL30236399 | 0.85 | RAF1 (0.56) | MAPK14LCKKDRJAK3BRAF | |
| SCHEMBL30236585 | 0.82 | BRAF (0.68) | MAPK14LCKKDRJAK3BRAF | |
| SCHEMBL29272266 | 0.82 | BRAF (0.68) | MAPK14LCKKDRJAK3BRAF | |
| SCHEMBL29272118 | 0.81 | LCK (0.51) | MAPK14LCKKDRJAK3BRAF | |
| SCHEMBL30236675 | 0.81 | LCK (0.51) | MAPK14LCKKDRJAK3BRAF | |
| SCHEMBL30236582 | 0.79 | RAF1 (0.57) | MAPK14LCKKDRJAK3BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4399210-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | Black Diamond Therapeutics, Inc. (US) | 2024-07-17 | — | — | EP | disclosed |
| CN-118159537-A | 6-Aza-quinoline derivatives and related uses | 黑钻治疗公司 | 2024-06-07 | — | — | CN | disclosed |
| WO-2023039505-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2023-03-16 | — | — | WO | disclosed |