Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 9/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29272363 | 1.00 | ORAI1 (0.46) | ORAI1BRAFMAPTTP53RAF1 | |
| SCHEMBL30236380 | 0.90 | MAPK14 (0.53) | ORAI1BRAFMAPTTP53RAF1 | |
| SCHEMBL29272411 | 0.90 | MAPK14 (0.53) | ORAI1BRAFMAPTTP53RAF1 | |
| SCHEMBL29272400 | 0.85 | RAF1 (0.58) | BRAFRAF1ALDH1A1MAPK14LCK | |
| SCHEMBL30237029 | 0.85 | RAF1 (0.58) | BRAFRAF1ALDH1A1MAPK14LCK | |
| SCHEMBL29272409 | 0.85 | LCK (0.61) | BRAFRAF1MAPK14LCKKDR | |
| SCHEMBL29272078 | 0.84 | RAF1 (0.55) | BRAFRAF1MAPK14LCKKDR | |
| SCHEMBL30236692 | 0.84 | RAF1 (0.55) | BRAFRAF1MAPK14LCKKDR | |
| SCHEMBL30236302 | 0.82 | BRAF (0.62) | BRAFRAF1CYP2C9 | |
| SCHEMBL29272329 | 0.82 | BRAF (0.62) | BRAFRAF1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4399210-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | Black Diamond Therapeutics, Inc. (US) | 2024-07-17 | — | — | EP | disclosed |
| CN-118159537-A | 6-Aza-quinoline derivatives and related uses | 黑钻治疗公司 | 2024-06-07 | — | — | CN | disclosed |
| WO-2023039505-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2023-03-16 | — | — | WO | disclosed |