Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | KRAS | P01116 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30237345 | 0.86 | ABL1 (0.54) | ABL1BRAFLCKKDRALOX15 | |
| SCHEMBL30236557 | 0.83 | ABL1 (0.46) | ABL1BRAFKRASRAF1LCK | |
| SCHEMBL30236957 | 0.81 | HTT (0.40) | ABL1BRAFLCKKDRJAK3 | |
| SCHEMBL29272122 | 0.81 | HTT (0.40) | ABL1BRAFLCKKDRJAK3 | |
| SCHEMBL15289623 | 0.80 | RAF1 (0.40) | ABL1BRAFKRASRAF1LCK | |
| SCHEMBL31032234 | 0.79 | PDGFRB (0.43) | ABL1BRAFKRASRAF1KDR | |
| SCHEMBL30236037 | 0.77 | RAF1 (0.41) | ABL1BRAFKRASRAF1LCK | |
| SCHEMBL5489201 | 0.76 | LCK (0.53) | ABL1BRAFLCKKDRJAK3 | |
| SCHEMBL30236413 | 0.76 | ABL1 (0.36) | ABL1BRAFKRASRAF1LCK | |
| SCHEMBL29877852 | 0.76 | KDR (0.45) | ABL1BRAFKRASRAF1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4399210-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | Black Diamond Therapeutics, Inc. (US) | 2024-07-17 | — | — | EP | disclosed |
| CN-118159537-A | 6-Aza-quinoline derivatives and related uses | 黑钻治疗公司 | 2024-06-07 | — | — | CN | disclosed |
| WO-2023039505-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2023-03-16 | — | — | WO | disclosed |