Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 18/20 | 0.43 |
| ▸ | BRAF | P15056 | 17/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | ARAF | P10398 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30237149 | 1.00 | RAF1 (0.43) | RAF1BRAFABL1ARAFKDR | |
| SCHEMBL30236928 | 1.00 | RAF1 (0.43) | RAF1BRAFABL1ARAFKDR | |
| SCHEMBL29272159 | 1.00 | RAF1 (0.43) | RAF1BRAFABL1ARAFKDR | |
| SCHEMBL30236871 | 0.90 | LCK (0.48) | RAF1BRAFABL1KDRLCK | |
| SCHEMBL30237067 | 0.90 | LCK (0.48) | RAF1BRAFABL1KDRLCK | |
| SCHEMBL29272158 | 0.90 | LCK (0.48) | RAF1BRAFABL1KDRLCK | |
| SCHEMBL30236274 | 0.90 | LCK (0.48) | RAF1BRAFABL1KDRLCK | |
| SCHEMBL29272482 | 0.86 | RAF1 (0.53) | RAF1BRAFKDRLCKJAK3 | |
| SCHEMBL30236184 | 0.86 | RAF1 (0.53) | RAF1BRAFKDRLCKJAK3 | |
| SCHEMBL30236178 | 0.86 | RAF1 (0.44) | RAF1BRAFABL1ARAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4399210-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | Black Diamond Therapeutics, Inc. (US) | 2024-07-17 | — | — | EP | disclosed |
| WO-2023039505-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2023-03-16 | — | — | WO | disclosed |