Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 8/20 | 0.48 |
| ▸ | KDR | P35968 | 8/20 | 0.48 |
| ▸ | JAK3 | P52333 | 8/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.48 |
| ▸ | TEK | Q02763 | 4/20 | 0.45 |
| ▸ | BRAF | P15056 | 4/20 | 0.44 |
| ▸ | RAF1 | P04049 | 5/20 | 0.43 |
| ▸ | KRAS | P01116 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 7/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30236274 | 1.00 | LCK (0.48) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL29272158 | 1.00 | LCK (0.48) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL30236871 | 1.00 | LCK (0.48) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL30237149 | 0.90 | RAF1 (0.43) | LCKKDRJAK3MAPK14BRAF | |
| SCHEMBL29272159 | 0.90 | RAF1 (0.43) | LCKKDRJAK3MAPK14BRAF | |
| SCHEMBL30236928 | 0.90 | RAF1 (0.43) | LCKKDRJAK3MAPK14BRAF | |
| SCHEMBL30237193 | 0.90 | RAF1 (0.43) | LCKKDRJAK3MAPK14BRAF | |
| SCHEMBL30237051 | 0.87 | BRAF (0.45) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL29272264 | 0.86 | KDR (0.59) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL30236705 | 0.86 | KDR (0.59) | LCKKDRJAK3MAPK14TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4399210-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | Black Diamond Therapeutics, Inc. (US) | 2024-07-17 | — | — | EP | disclosed |
| WO-2023039505-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2023-03-16 | — | — | WO | disclosed |