Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 4/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RBBP5 | Q15291 | 1/20 | 0.37 |
| ▸ | DPY30 | Q9C005 | 1/20 | 0.37 |
| ▸ | ASH2L | Q9UBL3 | 1/20 | 0.37 |
| ▸ | AMD1 | P17707 | 1/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | AHCY | P23526 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31533318 | 0.94 | DOT1L (0.48) | DOT1LRXFP1PI4KAPI4K2BPI4K2A | |
| SCHEMBL30239003 | 0.92 | RXFP1 (0.43) | DOT1LRXFP1PI4KAPI4K2BPI4K2A | |
| SCHEMBL31533320 | 0.88 | DOT1L (0.47) | DOT1LRXFP1PI4KAPI4K2BPI4K2A | |
| SCHEMBL30239396 | 0.87 | DOT1L (0.57) | DOT1LRXFP1PI4KAPI4K2BPI4K2A | |
| SCHEMBL30238891 | 0.86 | DOT1L (0.47) | DOT1LRXFP1PI4KAPI4K2BPI4K2A | |
| SCHEMBL30239294 | 0.84 | RXFP1 (0.43) | DOT1LRXFP1PI4KAPI4K2BPI4K2A | |
| SCHEMBL31533319 | 0.84 | RXFP1 (0.43) | DOT1LRXFP1PI4KAPI4K2BPI4K2A | |
| SCHEMBL30239717 | 0.83 | DOT1L (0.50) | DOT1LRXFP1PI4KAPI4K2BPI4K2A | |
| SCHEMBL30239308 | 0.82 | HTRA2 (0.41) | DOT1L | |
| SCHEMBL31001611 | 0.82 | DOT1L (0.48) | DOT1LRXFP1PI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4374157-A2 | FRET-BASED ASSAYS | The General Hospital Corporation (US) | 2024-05-29 | — | — | EP | disclosed |
| WO-2023004438-A2 | FRET-BASED ASSAYS | THE GENERAL HOSPITAL CORPORATION (US) | 2023-01-26 | — | — | WO | disclosed |