Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.68 |
| ▸ | ABL1 | P00519 | 2/20 | 0.68 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.68 |
| ▸ | AURKA | O14965 | 1/20 | 0.68 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.68 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.68 |
| ▸ | CSF1R | P07333 | 1/20 | 0.68 |
| ▸ | RET | P07949 | 1/20 | 0.68 |
| ▸ | MET | P08581 | 1/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.68 |
| ▸ | PIM1 | P11309 | 1/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.68 |
| ▸ | FLT1 | P17948 | 1/20 | 0.68 |
| ▸ | LTK | P29376 | 1/20 | 0.68 |
| ▸ | GRK5 | P34947 | 1/20 | 0.68 |
| ▸ | KDR | P35968 | 1/20 | 0.68 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24963530 | 0.90 | LRRK2 (0.53) | LRRK2ABL1CHEK1AURKADAPK3 | |
| SCHEMBL5873863 | 0.83 | KDR (1.00) | LRRK2ABL1CHEK1AURKADAPK3 | |
| SCHEMBL11192094 | 0.74 | AKT2 (0.68) | LRRK2CHEK1CNR1CNR2GPR55 | |
| SCHEMBL13854137 | 0.73 | ABL1 (0.74) | LRRK2ABL1CHEK1AURKADAPK3 | |
| SCHEMBL13854158 | 0.71 | ABL1 (0.67) | LRRK2ABL1CHEK1AURKADAPK3 | |
| SCHEMBL3141083 | 0.71 | ABL1 (0.76) | LRRK2ABL1CHEK1AURKADAPK3 | |
| SCHEMBL23524008 | 0.71 | ABL1 (0.66) | LRRK2ABL1CHEK1AURKADAPK3 | |
| SCHEMBL30239363 | 0.71 | PDE3B (0.56) | LRRK2 | |
| SCHEMBL24964988 | 0.69 | IKBKB (0.58) | LRRK2CHEK1IKBKECNR1CNR2 | |
| SCHEMBL1396298 | 0.69 | ABL1 (0.67) | LRRK2ABL1CHEK1AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023004280-A1 | SELECTIVE PYRAZOLE LRRK2 INHIBITORS AND METHODS FOR USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2023-01-26 | — | — | WO | claimed |