Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.76 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.76 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.76 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.76 |
| ▸ | AURKA | O14965 | 1/20 | 0.76 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.76 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.76 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.76 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.76 |
| ▸ | CSF1R | P07333 | 1/20 | 0.76 |
| ▸ | RET | P07949 | 1/20 | 0.76 |
| ▸ | MET | P08581 | 1/20 | 0.76 |
| ▸ | PIM1 | P11309 | 1/20 | 0.76 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.76 |
| ▸ | FLT1 | P17948 | 1/20 | 0.76 |
| ▸ | LTK | P29376 | 1/20 | 0.76 |
| ▸ | GRK5 | P34947 | 1/20 | 0.76 |
| ▸ | KDR | P35968 | 1/20 | 0.76 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.76 |
| ▸ | FLT3 | P36888 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873863 | 0.86 | KDR (1.00) | ABL1PDGFRBPDGFRACHEK1AURKA | |
| SCHEMBL13854137 | 0.79 | ABL1 (0.74) | ABL1PDGFRBPDGFRACHEK1AURKA | |
| SCHEMBL1900363 | 0.78 | PGR (0.68) | TDP2CYP11B1CYP11B2PARP10PARP11 | |
| SCHEMBL1396298 | 0.77 | ABL1 (0.67) | ABL1PDGFRBPDGFRACHEK1AURKA | |
| SCHEMBL16176494 | 0.75 | BTK (1.00) | ABL1PDGFRBPDGFRACHEK1AURKA | |
| SCHEMBL13854158 | 0.74 | ABL1 (0.67) | ABL1PDGFRBPDGFRACHEK1AURKA | |
| SCHEMBL5873776 | 0.74 | PDGFRB (0.67) | ABL1PDGFRBPDGFRACHEK1AURKA | |
| SCHEMBL5873962 | 0.74 | ABL1 (0.67) | ABL1PDGFRBPDGFRACHEK1AURKA | |
| SCHEMBL13854136 | 0.74 | CDK9 (0.66) | ABL1PDGFRBPDGFRACHEK1AURKA | |
| SCHEMBL30239369 | 0.71 | LRRK2 (0.68) | ABL1PDGFRBPDGFRACHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807425-B1 | PYRIDINE IMIDAZOLES AND AZA-INDOLES AS PROGESTERONE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-07-30 | — | — | EP | disclosed |
| EP-1807425-B1 | PYRIDINE IMIDAZOLES AND AZA-INDOLES AS PROGESTERONE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-07-30 | — | — | EP | disclosed |
| EP-2502925-A1 | Pyridine imidazoles and aza-indoles as progesterone receptor modulators | Janssen Pharmaceutica NV (BE) | 2012-09-26 | — | — | EP | disclosed |
| EP-2502925-A1 | Pyridine imidazoles and aza-indoles as progesterone receptor modulators | Janssen Pharmaceutica NV (BE) | 2012-09-26 | — | — | EP | disclosed |
| CN-101087789-B | Pyridine imidazoles and aza-indoles as progesterone receptor modulators | JANSSEN PHARMACEUTICA NV | 2011-01-12 | — | — | CN | disclosed |
| EP-1490365-B1 | AZAINDOLES AS INHIBITORS OF C-JUN N-TERMINAL KINASES | EISAI R&D MAN CO LTD (JP) | 2010-02-10 | — | — | EP | disclosed |
| EP-1490365-B1 | AZAINDOLES AS INHIBITORS OF C-JUN N-TERMINAL KINASES | EISAI R&D MAN CO LTD (JP) | 2010-02-10 | — | — | EP | disclosed |
| US-20100016266-A1 | Pyridine Imidazoles and Aza-indoles as Progesterone Receptor Modulators | JIANG WEIQIN | 2010-01-21 | — | — | US | disclosed |
| US-20100016266-A1 | Pyridine Imidazoles and Aza-indoles as Progesterone Receptor Modulators | JIANG WEIQIN | 2010-01-21 | — | — | US | disclosed |
| US-20100016266-A1 | Pyridine Imidazoles and Aza-indoles as Progesterone Receptor Modulators | JIANG WEIQIN | 2010-01-21 | — | — | US | disclosed |
| US-20060111390-A1 | Azaindoles as inhibitors of c-jun n-terminal kinases | EISAI CO., LTD. (JP) | 2006-05-25 | — | — | US | disclosed |
| US-20060111391-A1 | Pyridine imidazoles and aza-indoles as progesterone receptor modulators | JANSSEN PHAMACEUTICA N.V. (BE) | 2006-05-25 | — | — | US | disclosed |
| WO-2006049890-A1 | PYRIDINE IMIDAZOLES AND AZA-INDOLES AS PROGESTERONE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-11 | — | — | WO | disclosed |
| US-20050272761-A1 | 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders | EISAI CO., LTD. (JP) | 2005-12-08 | — | — | US | disclosed |
| CN-1656094-A | 7-azaindoles as inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders | EISAI CO LTD (JP) | 2005-08-17 | — | — | CN | disclosed |
| CN-1649869-A | Azaindoles as c-Jun N-terminal Kinase Inhibitors | EISAI CO LTD (JP) | 2005-08-03 | — | — | CN | disclosed |
| EP-1490365-A1 | AZAINDOLES AS INHIBITORS OF C-JUN N-TERMINAL KINASES | Eisai Co., Ltd. (JP) | 2004-12-29 | — | — | EP | disclosed |
| EP-1490364-A1 | 7-AZAINDOLES AS INHIBITORS OF C-JUN N-TERMINAL KINASES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Eisai Co., Ltd. (JP) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003082868-A1 | 7-AZAINDOLES AS INHIBITORS OF C-JUN N-TERMINAL KINASES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | EISAI CO., LTD. (JP) | 2003-10-09 | — | — | WO | disclosed |
| WO-2003082869-A1 | AZAINDOLES AS INHIBITORS OF C-JUN N-TERMINAL KINASES | EISAI CO., LTD. (JP) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272761-A1 | 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders | API5, MAPKAPK5, MAP3K5 | ABL1 1938/4885PDGFRB 3598/4885PDGFRA 3292/4885 |
| US-20060111390-A1 | Azaindoles as inhibitors of c-jun n-terminal kinases | API5, CDK5, AZI2 | ABL1 363/4885PDGFRB 1778/4885PDGFRA 1411/4885 |
| US-20060111391-A1 | Pyridine imidazoles and aza-indoles as progesterone receptor modulators | PGR, GPER1, FSHR | ABL1 1117/4885PDGFRB 309/4885PDGFRA 243/4885 |
| US-20100016266-A1 | Pyridine Imidazoles and Aza-indoles as Progesterone Receptor Modulators | PGR, GPER1, FSHR | ABL1 1117/4885PDGFRB 309/4885PDGFRA 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.