Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 2/20 | 0.52 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.52 |
| ▸ | KCNQ4 | P56696 | 2/20 | 0.52 |
| ▸ | KCNQ5 | Q9NR82 | 2/20 | 0.52 |
| ▸ | GCGR | P47871 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 2/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23902673 | 1.00 | KCNQ3 (0.52) | KCNQ3KCNQ2KCNQ4KCNQ5GCGR | |
| SCHEMBL23902658 | 0.89 | EGFR (0.55) | KCNQ3KCNQ2KCNQ4KCNQ5GCGR | |
| SCHEMBL30241341 | 0.89 | EGFR (0.55) | KCNQ3KCNQ2KCNQ4KCNQ5GCGR | |
| SCHEMBL30241388 | 0.84 | KCNQ3 (0.66) | KCNQ3KCNQ2KCNQ4KCNQ5EGFR | |
| SCHEMBL23902686 | 0.84 | KCNQ3 (0.66) | KCNQ3KCNQ2KCNQ4KCNQ5EGFR | |
| SCHEMBL23902645 | 0.82 | ERBB2 (0.60) | KCNQ3KCNQ2KCNQ4KCNQ5EGFR | |
| SCHEMBL30241481 | 0.82 | ERBB2 (0.60) | KCNQ3KCNQ2KCNQ4KCNQ5EGFR | |
| SCHEMBL23902638 | 0.82 | EGFR (0.51) | KCNQ3KCNQ2KCNQ4KCNQ5EGFR | |
| SCHEMBL30364613 | 0.82 | EGFR (0.51) | KCNQ3KCNQ2KCNQ4KCNQ5EGFR | |
| SCHEMBL23902662 | 0.82 | KCNQ3 (0.53) | KCNQ3KCNQ2KCNQ4KCNQ5EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4132907-A1 | (1 H-INDOL-5-YL)ACRYLAMIDE DERIVATIVES AS INHIBITORS OF TEAD PROTEINS AND THE HIPPO-YAP1/TAZ SIGNALING CASCADE FOR THE TREATMENT OF CANCER | SANOFI (FR) | 2023-02-15 | — | — | EP | claimed |
| CN-115667216-A | (1H-indol-5-yl) acrylamide derivatives as TEAD proteins and inhibitors of the HIPPO-YAP1/TAZ signaling cascade for the treatment of cancer | 赛诺菲 | 2023-01-31 | — | — | CN | claimed |
| CN-115667216-B | (1H-indol-5-yl) acrylamide derivatives as inhibitors of TEAD proteins and HIPPO-YAP1/TAZ signaling cascades for the treatment of cancer | 赛诺菲 | 2025-02-18 | — | — | CN | disclosed |
| EP-4132907-A1 | (1 H-INDOL-5-YL)ACRYLAMIDE DERIVATIVES AS INHIBITORS OF TEAD PROTEINS AND THE HIPPO-YAP1/TAZ SIGNALING CASCADE FOR THE TREATMENT OF CANCER | SANOFI (FR) | 2023-02-15 | — | — | EP | disclosed |
| CN-115667216-A | (1H-indol-5-yl) acrylamide derivatives as TEAD proteins and inhibitors of the HIPPO-YAP1/TAZ signaling cascade for the treatment of cancer | 赛诺菲 | 2023-01-31 | — | — | CN | disclosed |