Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alvelestat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE known ✓ | P08246 | 20/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alvelestat SCHEMBL3021295 | 0.93 | ELANE (0.91) | ELANE | |
| Alvelestat SCHEMBL29989873 | 0.93 | ELANE (0.91) | ELANE | |
| Alvelestat SCHEMBL29740084 | 0.92 | ELANE (1.00) | ELANE | |
| Alvelestat SCHEMBL30179302 | 0.92 | ELANE (1.00) | ELANE | |
| Alvelestat SCHEMBL29519811 | 0.92 | ELANE (1.00) | ELANE | |
| Alvelestat SCHEMBL560757 | 0.92 | ELANE (1.00) | ELANE | |
| SCHEMBL3716773 | 0.85 | ELANE (0.76) | ELANE | |
| SCHEMBL25359179 | 0.84 | ELANE (0.83) | ELANE | |
| SCHEMBL15398026 | 0.80 | ELANE (0.75) | ELANE | |
| SCHEMBL4126035 | 0.80 | ELANE (0.74) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120269872-A1 | NOVEL SALT 628 | ASTRAZENECA AB (SE) | 2012-10-25 | — | — | US | disclosed |
| US-8232296-B2 | Salt 628 | ASTRAZENECA AB (SE) | 2012-07-31 | — | — | US | disclosed |
| US-20100216843-A1 | NOVEL SALT 628 | ASTRAZENECA R&D | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120269872-A1 | NOVEL SALT 628 | REN, SCN8A, SLC38A7 | ELANE 1755/4885 |
| US-20100216843-A1 | NOVEL SALT 628 | REN, SCN8A, SLC38A7 | ELANE 2508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.