Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 12/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 4/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28415530 | 1.00 | AURKA (0.40) | AURKAAURKBSRCGSK3BEIF2AK2 | |
| SCHEMBL28416436 | 0.93 | AURKA (0.38) | AURKAAURKBSRCGSK3BEIF2AK2 | |
| SCHEMBL30250129 | 0.93 | AURKA (0.38) | AURKAAURKBSRCGSK3BEIF2AK2 | |
| SCHEMBL28409102 | 0.87 | AURKA (0.55) | AURKAAURKBSRCGSK3BEIF2AK2 | |
| SCHEMBL30249931 | 0.85 | AURKA (0.39) | AURKAAURKBSRCGSK3BEIF2AK2 | |
| SCHEMBL30249999 | 0.82 | PAK1 (0.45) | AURKAAURKBSRCGSK3BEIF2AK2 | |
| SCHEMBL24668009 | 0.81 | AURKA (0.54) | AURKAAURKBSRCGSK3BEIF2AK2 | |
| SCHEMBL30250187 | 0.81 | AURKA (0.54) | AURKAAURKBSRCGSK3BEIF2AK2 | |
| SCHEMBL28411559 | 0.78 | RET (0.44) | AURKAAURKBSRCGSK3BPAK4 | |
| SCHEMBL30250267 | 0.78 | RET (0.44) | AURKAAURKBSRCGSK3BPAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285882-B | Fused ring compound, pharmaceutical composition containing same, and preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2022-12-02 | — | — | CN | disclosed |