Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LPL | P06858 | 11/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 11/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25267227 | 0.86 | LPL (0.41) | LMNATP53HTTLPLLIPG | |
| SCHEMBL25207380 | 0.86 | LPL (0.41) | LMNATP53HTTLPLLIPG | |
| Hydrochloric Acid SCHEMBL25260965 | 0.84 | LPL (0.40) | LMNATP53HTTLPLLIPG | |
| SCHEMBL9910113 | 0.84 | PDE2A (0.44) | LPLLIPGAAK1CA1CA2 | |
| SCHEMBL2699826 | 0.84 | PDE2A (0.44) | LPLLIPGAAK1CA1CA2 | |
| Hydrochloric Acid SCHEMBL25260963 | 0.84 | LPL (0.40) | LMNATP53HTTLPLLIPG | |
| SCHEMBL2411421 | 0.83 | LPL (0.44) | LPLLIPGAAK1CA1CA2 | |
| SCHEMBL14758481 | 0.82 | AAK1 (0.40) | LPLLIPGAAK1CA1CA2 | |
| SCHEMBL31294725 | 0.81 | LPL (0.46) | LPLLIPGCA1CA2CA9 | |
| SCHEMBL4578027 | 0.80 | AAK1 (0.39) | LPLLIPGAAK1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396301-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | Jerini AG (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091876-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2010-08-19 | — | — | WO | disclosed |