Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | CTSL | P07711 | 2/20 | 0.48 |
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | CTSC | P53634 | 2/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3555704 | 0.85 | TP53 (0.42) | KMT2ATP53SMN1; SMN2MEN1POLB | |
| SCHEMBL3937977 | 0.85 | TP53 (0.42) | KMT2ATP53SMN1; SMN2MEN1POLB | |
| SCHEMBL3556277 | 0.85 | TSHR (0.45) | KMT2ATP53SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL301872 | 0.78 | NAMPT (0.47) | KMT2ATP53MEN1POLB | |
| SCHEMBL3562435 | 0.76 | L3MBTL1 (0.53) | L3MBTL1SMN1; SMN2POLBHSD17B10LMNA | |
| SCHEMBL3556125 | 0.76 | POLB (0.45) | KMT2AL3MBTL1TP53SMN1; SMN2MEN1 | |
| SCHEMBL301780 | 0.76 | TP53 (0.46) | KMT2ATP53SMN1; SMN2MEN1LMNA | |
| SCHEMBL3556390 | 0.76 | TSHR (0.44) | TP53SMN1; SMN2NPSR1POLBLMNA | |
| SCHEMBL301836 | 0.76 | KDM4E (0.45) | KMT2ATP53NPSR1MEN1POLB | |
| SCHEMBL3556286 | 0.76 | KDM4E (0.45) | KMT2ATP53NPSR1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4851328-B2 | — | — | 2012-01-11 | — | — | JP | claimed |
| JP-2007506692-A | — | — | 2007-03-22 | — | — | JP | claimed |
| EP-1670470-A1 | PYRIDINE DERIVATIVES AND USE THEREOF AS UROTENSIN II ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2006-06-21 | — | — | EP | claimed |
| WO-2005030209-A1 | PYRIDINE DERIVATIVES AND USE THEREOF AS UROTENSIN II ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-04-07 | — | — | WO | claimed |