Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 14/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.61 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.61 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.61 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30262057 | 0.92 | FGFR4 (0.54) | FGFR4FGFR1FGFR2FGFR3MAPK3 | |
| SCHEMBL30262059 | 0.90 | FGFR1 (0.57) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16071541 | 0.89 | FGFR4 (0.67) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL30261983 | 0.86 | FGFR4 (0.47) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| Trifluoroacetic Acid SCHEMBL30262048 | 0.85 | FGFR4 (0.48) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL30262052 | 0.83 | FGFR4 (0.65) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL30261946 | 0.82 | FGFR1 (0.75) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16137314 | 0.81 | FGFR1 (0.63) | FGFR4FGFR1FGFR2FGFR3MAPK3 | |
| SCHEMBL16137331 | 0.80 | FGFR1 (0.62) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL16071592 | 0.80 | FGFR1 (0.67) | FGFR4FGFR1FGFR2FGFR3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023039828-A1 | FUSED RING COMPOUNDS AS INHIBITORS OF FGFR4 TYROSINE KINASES | NUTSHELL BIOTECH (SHANGHAI) CO., LTD. (CN) | 2023-03-23 | — | — | WO | disclosed |