SCHEMBL30263261

SCHEMBL30263261

NC(=O)c1ncc(N2CCCC2)cc1-c1nc(-c2ccccc2Cl)cs1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 3/20 0.46
CYP1B1 Q16678 3/20 0.46
KDM4E B2RXH2 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
CYP19A1 P11511 1/20 0.45
EIF4E P06730 4/20 0.44
ATP4A P20648 2/20 0.41
ATP4B P51164 2/20 0.41
CYP1A2 P05177 2/20 0.41
LMNA P02545 1/20 0.39
MAPT P10636 1/20 0.39
KMT2A Q03164 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
HTR2C P28335 2/20 0.39
ALDH1A1 P00352 1/20 0.38
HPGD P15428 1/20 0.38
HTT P42858 1/20 0.38
GSTO1 P78417 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30263260 0.91 CYP1B1 (0.57) CYP1A1CYP1B1KDM4ESMN1; SMN2NPC1
Hydrochloric Acid SCHEMBL30263248 0.91 CYP1A1 (0.43) CYP1A1CYP1B1KDM4ESMN1; SMN2NPC1
SCHEMBL30292542 0.91 CYP1A1 (0.43) CYP1A1CYP1B1KDM4ESMN1; SMN2NPC1
SCHEMBL30263341 0.89 UCHL1 (0.41) CYP1A1CYP1B1KDM4ESMN1; SMN2NPC1
SCHEMBL30292484 0.89 CYP1A1 (0.42) CYP1A1CYP1B1KDM4ESMN1; SMN2NPC1
SCHEMBL30263168 0.88 CYP1A1 (0.45) CYP1A1CYP1B1KDM4ESMN1; SMN2NPC1
SCHEMBL30263306 0.88 CYP1A1 (0.41) CYP1A1CYP1B1KDM4ESMN1; SMN2NPC1
SCHEMBL30292498 0.88 KDM4E (0.42) CYP1A1CYP1B1KDM4ESMN1; SMN2NPC1
SCHEMBL30292570 0.88 CYP1A1 (0.41) CYP1A1CYP1B1KDM4ESMN1; SMN2NPC1
SCHEMBL30292530 0.87 CYP1A1 (0.41) CYP1A1CYP1B1KDM4ESMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4161921-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF Anima Biotech Inc. (US) 2023-04-12 EP disclosed
CN-115916776-A Collagen 1 translation inhibitors and methods of use thereof 艾尼莫生物科技公司 2023-04-04 CN disclosed