SCHEMBL30263291

SCHEMBL30263291

Cc1cnc(C(N)=O)c(-c2nc(-c3ccccc3Cl)cs2)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.50
CYP19A1 P11511 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
LMNA P02545 3/20 0.48
ATP4A P20648 2/20 0.48
ATP4B P51164 2/20 0.48
KMT2A Q03164 2/20 0.48
MAPT P10636 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
EIF4E P06730 5/20 0.46
CYP1A1 P04798 2/20 0.45
CYP1A2 P05177 2/20 0.45
CYP1B1 Q16678 2/20 0.45
ALDH1A1 P00352 1/20 0.42
HPGD P15428 1/20 0.42
HTT P42858 1/20 0.42
GSTO1 P78417 1/20 0.41
GRM2 Q14416 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30263205 0.86 SMN1; SMN2 (0.50) KDM4ECYP19A1SMN1; SMN2NPC1RAB9A
SCHEMBL30263347 0.82 CYP19A1 (0.63) KDM4ECYP19A1SMN1; SMN2NPC1RAB9A
SCHEMBL30263328 0.81 CYP19A1 (0.55) KDM4ECYP19A1SMN1; SMN2NPC1RAB9A
SCHEMBL30263261 0.81 CYP1A1 (0.46) KDM4ECYP19A1SMN1; SMN2NPC1RAB9A
SCHEMBL30292555 0.79 NPC1 (0.44) KDM4ECYP19A1SMN1; SMN2NPC1RAB9A
SCHEMBL30263260 0.79 CYP1B1 (0.57) KDM4ECYP19A1SMN1; SMN2NPC1RAB9A
SCHEMBL30292574 0.79 MAPK1 (0.43) KDM4ECYP19A1SMN1; SMN2NPC1RAB9A
SCHEMBL30263241 0.78 KDM4E (0.47) KDM4ECYP19A1SMN1; SMN2NPC1RAB9A
Hydrochloric Acid SCHEMBL30263248 0.78 CYP1A1 (0.43) KDM4ECYP19A1SMN1; SMN2NPC1RAB9A
SCHEMBL30263390 0.76 SMN1; SMN2 (0.49) KDM4ECYP19A1SMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4161921-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF Anima Biotech Inc. (US) 2023-04-12 EP disclosed
CN-115916776-A Collagen 1 translation inhibitors and methods of use thereof 艾尼莫生物科技公司 2023-04-04 CN disclosed