Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | VDR | P11473 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | BRD1 | O95696 | 2/20 | 0.43 |
| ▸ | TAF1 | P21675 | 2/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31397357 | 0.87 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDVDRMAPT | |
| SCHEMBL30273729 | 0.81 | KMT2A (0.50) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL30273799 | 0.78 | KDM4E (0.49) | KDM4EALDH1A1HPGDVDRMAPT | |
| SCHEMBL30274009 | 0.78 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDVDRMAPT | |
| SCHEMBL30273763 | 0.77 | MEN1 (0.46) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL17231447 | 0.75 | KDM4E (0.72) | KDM4EALDH1A1HPGDVDRMAPT | |
| SCHEMBL24943443 | 0.74 | KDM4E (0.67) | KDM4EALDH1A1HPGDVDRMAPT | |
| SCHEMBL26546204 | 0.74 | KDM4E (0.61) | KDM4EALDH1A1HPGDVDRMAPT | |
| SCHEMBL17231436 | 0.72 | KDM4E (0.67) | KDM4EALDH1A1HPGDVDRMAPT | |
| SCHEMBL26546218 | 0.72 | KDM4E (0.57) | KDM4EALDH1A1HPGDVDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250302815-A1 | PROTEIN TYROSINE PHOSPHATASE TARGETING LIGANDS | CALICO LIFE SCIENCES LLC | 2025-10-02 | — | — | US | disclosed |
| WO-2023019166-A1 | PROTEIN TYROSINE PHOSPHATASE TARGETING LIGANDS | CALICO LIFE SCIENCES LLC (US) | 2023-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250302815-A1 | PROTEIN TYROSINE PHOSPHATASE TARGETING LIGANDS | PTPN1, PTPN2, PTPN18 | KDM4E 2019/4885ALDH1A1 3874/4885HPGD 3365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.