Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.43 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13097046 | 1.00 | LRRK2 (0.44) | LRRK2CLK2AURKAAURKBINCENP | |
| SCHEMBL29447089 | 0.81 | CLK2 (0.46) | LRRK2CLK2AURKAAURKBINCENP | |
| SCHEMBL23753887 | 0.81 | MTOR (0.43) | LRRK2CLK2AURKAAURKBINCENP | |
| SCHEMBL15345105 | 0.79 | KDM5B (0.37) | AURKBMAPTIRAK4 | |
| SCHEMBL13086431 | 0.79 | IRAK1 (0.41) | LRRK2CLK2AURKAAURKBINCENP | |
| SCHEMBL24920777 | 0.79 | ACVR2A (0.46) | LRRK2CLK2AURKAAURKBINCENP | |
| SCHEMBL21425525 | 0.78 | CSF1R (0.41) | KDR | |
| SCHEMBL16561269 | 0.78 | MAPT (0.41) | LRRK2AURKAAURKBINCENPMKNK1 | |
| SCHEMBL24008090 | 0.78 | CLK2 (0.43) | LRRK2CLK2AURKAAURKBINCENP | |
| SCHEMBL24008092 | 0.78 | CLK2 (0.46) | LRRK2CLK2AURKAAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115768520-B | Substituted { 5-methoxy-6- [ (5-methoxypyridin-2-yl) methoxy ] pyridin-3-yl } methyl compounds as CSF-1R inhibitors | 伊莱利利公司 | 2024-06-07 | — | — | CN | disclosed |
| CN-115768520-A | Substituted { 5-methoxy-6- [ (5-methoxypyridin-2-yl) methoxy ] pyridin-3-yl } methyl compounds as CSF-1R inhibitors | 伊莱利利公司 | 2023-03-07 | — | — | CN | disclosed |