Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 14/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22578499 | 0.79 | PARP1 (0.53) | RPS6KA3CDK4CCND1MAPKAPK2PARP1 | |
| SCHEMBL19252945 | 0.76 | RPS6KA3 (0.53) | RPS6KA3MAPKAPK2CYP2D6HRH3 | |
| SCHEMBL22578354 | 0.75 | HRH3 (0.45) | RPS6KA3CDK4CCND1MAPKAPK2PARP1 | |
| SCHEMBL29879213 | 0.74 | HRH3 (0.45) | RPS6KA3CDK4CCND1MAPKAPK2PARP1 | |
| SCHEMBL38652638 | 0.73 | HRH3 (0.52) | RPS6KA3MAPKAPK2PARP1CYP2D6HRH3 | |
| SCHEMBL22570165 | 0.72 | CDK4 (0.50) | RPS6KA3CDK4CCND1MAPKAPK2PARP1 | |
| SCHEMBL20604877 | 0.72 | PARP1 (0.58) | RPS6KA3MAPKAPK2PARP1 | |
| SCHEMBL16088345 | 0.72 | CDK4 (0.51) | RPS6KA3CDK4CCND1MAPKAPK2PARP1 | |
| SCHEMBL4549832 | 0.72 | CDK4 (0.50) | RPS6KA3CDK4CCND1MAPKAPK2PARP1 | |
| SCHEMBL5389081 | 0.71 | RPS6KA3 (0.53) | RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115703792-B | Tricycle derivative and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2024-08-13 | — | — | CN | disclosed |
| CN-115703792-A | Tricyclic derivative and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2023-02-17 | — | — | CN | disclosed |