Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 6/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCND1 | P24385 | 2/20 | 0.39 |
| ▸ | RPS6KA2 | Q15349 | 6/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30104810 | 0.80 | HRH3 (0.42) | HRH3RPS6KA3MAPKAPK2CYP2D6PARP1 | |
| SCHEMBL38652638 | 0.77 | HRH3 (0.52) | HRH3RPS6KA3MAPKAPK2CYP2D6PARP1 | |
| SCHEMBL28849119 | 0.74 | HRH3 (0.42) | HRH3CYP2D6 | |
| SCHEMBL29878508 | 0.74 | HRH3 (0.42) | HRH3CYP2D6 | |
| SCHEMBL30967663 | 0.74 | RPS6KA3 (0.52) | HRH3RPS6KA3MAPKAPK2CYP2D6PARP1 | |
| SCHEMBL30276648 | 0.74 | RPS6KA3 (0.43) | HRH3RPS6KA3MAPKAPK2CYP2D6PARP1 | |
| SCHEMBL19252945 | 0.74 | RPS6KA3 (0.53) | HRH3RPS6KA3MAPKAPK2CYP2D6RPS6KA2 | |
| SCHEMBL22570165 | 0.72 | CDK4 (0.50) | HRH3RPS6KA3MAPKAPK2CYP2D6PARP1 | |
| SCHEMBL30172384 | 0.71 | RPS6KA3 (0.53) | HRH3RPS6KA3MAPKAPK2CYP2D6PARP1 | |
| SCHEMBL1393632 | 0.71 | RPS6KA3 (0.53) | HRH3RPS6KA3MAPKAPK2CYP2D6PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114940683-B | HPK1 inhibitors and uses thereof | 轩竹(北京)医药科技有限公司 | 2023-01-17 | — | — | CN | disclosed |
| CN-114940683-A | HPK1 inhibitors and uses thereof | 轩竹(北京)医药科技有限公司 | 2022-08-26 | — | — | CN | disclosed |