SCHEMBL30277935

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)O)[C@@H](C)CC)C(C)C

nearest known ligand 0.67

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	CALCR	P30988	5/20	0.61

▸	EP300	Q09472	1/20	0.58

▸	HIF1A	Q16665	1/20	0.58

▸	CALCRL	Q16602	2/20	0.56

▸	CRHR1	P34998	1/20	0.56

▸	CRHR2	Q13324	1/20	0.56

▸	F2	P00734	4/20	0.53

▸	HCRTR1	O43613	1/20	0.53

▸	HCRTR2	O43614	1/20	0.53

▸	GLP1R	P43220	1/20	0.53

▸	GCGR	P47871	1/20	0.53

▸	GIPR	P48546	1/20	0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL31000906	0.98	CALCR (0.59)	CALCREP300HIF1ACALCRLCRHR1
SCHEMBL30277946	0.95	CALCR (0.60)	CALCREP300HIF1ACALCRLGLP1R
SCHEMBL31000879	0.94	CALCRL (0.60)	CALCREP300HIF1ACALCRLCRHR1
SCHEMBL31000872	0.92	CALCR (0.60)	CALCREP300HIF1AF2HCRTR1
SCHEMBL30648485	0.91	CALCR (0.66)	CALCREP300HIF1ACRHR1CRHR2
SCHEMBL31000946	0.90	CALCR (0.64)	CALCREP300HIF1ACRHR1CRHR2
SCHEMBL30712880	0.90	CALCR (0.61)	CALCREP300HIF1ACRHR1CRHR2
SCHEMBL30495733	0.90	EP300 (0.66)	CALCREP300HIF1ACRHR1CRHR2
SCHEMBL30429242	0.90	CALCR (0.63)	CALCREP300HIF1ACRHR1CRHR2
SCHEMBL30804654	0.89	EP300 (0.60)	CALCREP300HIF1ACALCRLCRHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20240352445-A1	HUMANIZATION, AFFINITY MATURATION, AND OPTIMIZATION METHODS FOR PROTEINS AND ANTIBODIES	ABWIZ BIO, INC.	2024-10-24	—	—	US	disclosed
WO-2023019019-A2	HUMANIZATION, AFFINITY MATURATION, AND OPTIMIZATION METHODS FOR PROTEINS AND ANTIBODIES	ABWIZ BIO, INC. (US)	2023-02-16	—	—	WO	disclosed