SCHEMBL30277946

CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)O)C(C)C

nearest known ligand 0.64

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	CALCR	P30988	4/20	0.60

▸	CALCRL	Q16602	5/20	0.58

▸	EP300	Q09472	1/20	0.56

▸	HIF1A	Q16665	1/20	0.56

▸	EPHA2	P29317	2/20	0.54

▸	TFPI	P10646	2/20	0.54

▸	KEAP1	Q14145	1/20	0.53

▸	GLP1R	P43220	3/20	0.53

▸	GIPR	P48546	3/20	0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL31000879	0.97	CALCRL (0.60)	CALCRCALCRLEP300HIF1AKEAP1
SCHEMBL30277935	0.95	CALCR (0.61)	CALCRCALCRLEP300HIF1AGLP1R
SCHEMBL31000872	0.94	CALCR (0.60)	CALCREP300HIF1AKEAP1GLP1R
SCHEMBL31000906	0.93	CALCR (0.59)	CALCRCALCRLEP300HIF1AKEAP1
SCHEMBL30726592	0.93	CALCR (0.62)	CALCRCALCRLEP300HIF1A
SCHEMBL30607374	0.91	CALCR (0.58)	CALCREP300HIF1A
SCHEMBL30429242	0.89	CALCR (0.63)	CALCREP300HIF1A
SCHEMBL31182741	0.88	CALCR (0.62)	CALCREP300HIF1ATFPI
SCHEMBL30495657	0.88	EPHA2 (0.63)	CALCREP300HIF1AEPHA2TFPI
SCHEMBL30429340	0.88	OPRM1 (0.60)	CALCR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20240352445-A1	HUMANIZATION, AFFINITY MATURATION, AND OPTIMIZATION METHODS FOR PROTEINS AND ANTIBODIES	ABWIZ BIO, INC.	2024-10-24	—	—	US	disclosed
WO-2023019019-A2	HUMANIZATION, AFFINITY MATURATION, AND OPTIMIZATION METHODS FOR PROTEINS AND ANTIBODIES	ABWIZ BIO, INC. (US)	2023-02-16	—	—	WO	disclosed