Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | FLT1 | P17948 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.35 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30280430 | 1.00 | CHEK1 (0.37) | CHEK1DYRK1AAURKAJAK2PRKD3 | |
| SCHEMBL25153355 | 1.00 | CHEK1 (0.37) | CHEK1DYRK1AAURKAJAK2PRKD3 | |
| SCHEMBL25153360 | 0.86 | CHEK1 (0.37) | CHEK1DYRK1AAURKAJAK2PRKD3 | |
| SCHEMBL30280374 | 0.83 | CHEK1 (0.41) | CHEK1DYRK1AAURKAJAK2PRKD3 | |
| SCHEMBL25153268 | 0.83 | CHEK1 (0.41) | CHEK1DYRK1AAURKAJAK2PRKD3 | |
| SCHEMBL7513614 | 0.73 | CHEK1 (0.45) | CHEK1DYRK1AAURKAJAK2PRKD3 | |
| SCHEMBL30280407 | 0.73 | CHEK1 (0.45) | CHEK1DYRK1AAURKAJAK2PRKD3 | |
| SCHEMBL25153357 | 0.72 | ABL1 (0.41) | CHEK1DYRK1AAURKAJAK2PRKD3 | |
| SCHEMBL30280387 | 0.72 | ABL1 (0.41) | CHEK1DYRK1AAURKAJAK2PRKD3 | |
| SCHEMBL25153315 | 0.68 | CHEK1 (0.44) | CHEK1DYRK1AAURKAJAK2PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023064218-A1 | TYRO3 INHIBITORS | Halia Therapeutics, Inc. (US) | 2023-04-20 | — | — | WO | disclosed |